… cell lung cancer with EGFR ex20ins in this study. EGFR ex20ins, epidermal growth factor
receptor exon 20 … Several studies have proved that low TMB was associated with a survival …

… Patients with exon 20 insertions had a poor response to TKIs. However, the … with exon 20
insertions who undergo TKI treatments including gefitinib, erlotinib and afatinib do not respond …

… to the first and second-generation EGFR TKIs such as gefitinib, … Since only a subset of
patients with lung cancer respond to … Low TMB of EGFR ex20ins in this study likely reflected non-…

… mutation usually respond to epidermal growth factor receptor–tyrosine kinase inhibitors (EGFR-TKIs),
whereas T790M mutation and exon 20 … as compared with gefitinib or erlotinib for …

… erlotinib and gefitinib seemed to show inconsistent responses [12… variable responses to TKIs
and being associated with poor … Besides classical sensitizing mutations, exon 20 insertions …

… in exon 20 of the epidermal growth factor receptor (EGFR) gene were among the first EGFR
mutations to be … Low response rates of between 3–8% for erlotinib, gefitinib and the second …

… of lung cancer patients who had an excellent response to … either erlotinib or gefitinib in frontline
therapy for EGFR-mutated lung … a low ORR of 5% in 17 lung cancer patients with exon 20 …

… They found that G719A showed poor response to gefitinib, … shown poor responses in a
study of two lung cancer patient-… and H773_V774insNPH exon 20 insertion mutations [52]. …

… the clinical significance of rare exon 20 mutations in EGFR‑TKI‑… mutation patterns of
epidermal growth factor receptor gene associated with variable responses to gefitinib treatment in …

… in non–small-cell lung cancer predict sensitivity to EGFR … the treatment efficacy of afatinib,
erlotinib, and gefitinib according … EGFR exon 20 insertions and de novo T790M mutations are …